Psychiatrists currently use ketamine to treat mental health conditions, especially depression. Spravato, a nasal spray form of esketamine, provides a unique option for certain types of depression that haven’t responded to other treatments. Here is how Spravato is used for different conditions and how it compares to other ketamine-based therapies:

Major Depressive Disorder

Spravato is used to treat various mental health conditions. Major depressive disorder (MDD) is characterized by a prolonged feeling of sadness, low energy, and a lack of interest in daily activities. It can affect many aspects of life, such as relationships and work. The causes of MDD are complex and can include genetic, biological, psychological, and environmental factors. 

While psychiatrists may prescribe antidepressants, they don’t work for everyone. For those seeking alternative options, Spravato offers a different approach. Unlike traditional antidepressants, it works through a different mechanism that doesn’t rely on serotonin pathways. Spravato increases levels of glutamate, a chemical messenger in the brain.

Treatment-resistant Depression

Treatment-resistant depression (TRD) is a condition where depressive symptoms persist despite trying multiple standard therapies. Patients with TRD often face challenges, cycling through various antidepressants and psychotherapy with little relief. This complex situation may require exploring innovative treatments beyond conventional methods. One such option is Spravato, which can be used when multiple antidepressants have not produced significant improvement. Psychiatrists administer it as a nasal spray in a supervised clinical setting under the supervision of a healthcare professional.

The administration process involves weekly treatments for a specified period, under the supervision of a healthcare professional. A tapering plan is recommended to help maintain ongoing remission. If previous depression treatments have been limited in success, discussing TRD and potential options like Spravato with your healthcare provider can be beneficial.

Spravato Alternatives

Unlike Spravato, which professionals administer via nasal spray, healthcare providers give IV ketamine directly into the bloodstream through a controlled infusion. This method allows the medication to quickly circulate throughout the body and brain, leading to a rapid onset of therapeutic effects.

There are several differences between the two treatments. Spravato is approved for TRD, and its use must follow strict guidelines. Healthcare providers administer IV ketamine in various settings. While both treatments require clinical supervision, their dosing schedules and frequency differ.

Typically, professionals provide IV ketamine over multiple sessions. Spravato follows a structured schedule with tapering doses. Patients seeking immediate relief from symptoms might consider IV ketamine. Not everyone is eligible for this treatment, so healthcare providers must carefully evaluate each patient. Deciding between IV ketamine and Spravato depends on the patient’s medical history, recommendations from healthcare providers, and personal preferences regarding the method of delivery. 

Schedule an Appointment Near You

When exploring treatments like Spravato, consulting a psychiatric professional is a key step. These specialists can review your medical history, identify any conditions, and provide personalized advice on treatment options. Clinics offering Spravato typically require an appointment for evaluation to make sure patients meet specific criteria for its use. If you’re unsure where to start, finding a clinic experienced in ketamine-related therapies can help clarify your next steps. 

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